| Archaea | Bacteria |
| Types | |
| Methanogens, Thermophiles, and Halophiles | Gram-positive and Gram-negative |
| Cell Wall | |
| Pseudopeptidoglycan | Lipopolysaccharide/ Peptidoglycan |
| Metabolism Activity | |
| They perform modified form of glycolysis and citric acid cycle. | They perform glycolysis and citric acid cycle. |
| Cell membrane | |
| Ether-linked lipids | Ester-linked lipids |
| Thriving Habitat | |
| They can sustain in extremely harsh environments such as hot springs, marshlands, deep sea vents, and the gut of humans and ruminants. | They are found everywhere, including soil, organic matter, the earth’s crust, water, bodies of animals and plants, radioactive wastes, hot springs etc. |
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