e.g cromolyn sodium
Mechanism of action
Stabilize the mast cells so that release of histamine and other mediators is inhibited
through alteration in the function of delayed chloride channel in cell membrane. It has no role
once mediator is released and is used for casual prophylaxis.
Clinical uses
- Exercise and antigen induced asthma
- Occupational asthma
Side effects
Poorly absorbed so minimal side effect
Throat irritation, cough, dryness of mouth, chest tightness and wheezing
TREATMENT OF STATUS ASTHMATICS
Status asthmatics
Very sever and sustained attack of asthma which fails to respond to treatment with usual
measures
Management includes:- Administration of oxygen
- Frequent or continuous administration of aerosolized ß2 agonists like salbutamol
- Systemic corticosteroid like methyl prednisolone or hydrocortisone IV
- Aminophylline IV infusion
- Iv fluid to avoid dehydration
- Antibiotics in the presence of evidence of infection
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