Category: Drugs used to treat the diseases of blood, inflammation and gout

IndomethacinIndomethacin is slightly more toxic but in certain circumstances more effective than aspirin.Indomethacin is well absorbed after oral administration and highly bound to plasma proteins.Metabolism occurs in the liver and unchanged drug and inactive metabolites are excreted in bileand urine.Clinical Uses: treatment of patent ductus arteriosus, acute gouty arthritis and ankylosingspondylitis, pericarditis and pleurisy.Adverse Effects:…

AspirinAspirin and other nonsteroidal anti-inflammatory drugs are weak organic acids. They all inhibitprostaglandin biosynthesis. They decrease the production of free radicals and of superoxideand may interact with adenylyl cyclase to alter the cellular concentration of cAMP. Aspirin is thedrug of choice for treating the majority of articular and musculoskeletal disorders. It is also thestandard against…

IntroductionHemostasis is spontaneous arrest of bleeding from a damaged blood vessel. Steps: Vascularinjury Æ vasospasmÆ platelate adhesionÆ platelate aggregation Æ coagulation cascadesÆfibrin formationAnticoagulants are the drugs which inhibit fibrin formation.ClassificationBased on mechanism of action

IRONIron forms the nucleus of the iron porphyrin heme ring, which together with globin chains formshemoglobin that reversibly binds oxygen and provides the critical mechanism for oxygendelivery from lungs to other tissues. In the absence of adequate iron, small erythrocytes withinsufficient hemoglobin are formed resulting in microcytic hypochromic anemia.Causes of Iron Deficiency Anemia

Hematopoiesis, the production of circulating erythrocytes, platelets and leukocytes fromundifferentiated stem cells, is a remarkable process that produces over 200 billion new cells perday in the normal person and even greater number of blood cells in people with conditions thatcauses loss or destruction of blood cells. The hemopoietic machinery resides primarily in thebone marrow in…