{"id":6532,"date":"2024-11-16T11:12:25","date_gmt":"2024-11-16T11:12:25","guid":{"rendered":"https:\/\/workhouse.sweetdishy.com\/?p=6532"},"modified":"2024-11-16T11:12:26","modified_gmt":"2024-11-16T11:12:26","slug":"bioavailability","status":"publish","type":"post","link":"https:\/\/workhouse.sweetdishy.com\/index.php\/2024\/11\/16\/bioavailability\/","title":{"rendered":"Bioavailability:"},"content":{"rendered":"\n<p>It is the rate and amount of drug that is absorbed from a given dosage form and reaches the<br>systemic circulation following non-vascular administration. When the drug is given IV, the<br>bioavailability is 100%. It is important to know the manner in which a drug is absorbed. The<br>route of administration largely determines the latent period between administration and onset of<br>action. Drugs given by mouth may be inactive for the following reasons:<br>a) Enzymatic degradation of polypeptides within the lumen of the gastrointestinal tract e.g.<br>insulin, ACTH.<br>b) Poor absorption through gastrointestinal tract e.g. aminoglycoside antibiotic.<br>c) Inactivation by liver e.g. testosterone during first passage through the liver before it reaches<br>systemic circulation.<\/p>\n\n\n\n<ol start=\"3\" class=\"wp-block-list\">\n<li><strong>Factors affecting drug absorption and bioavailability:<br><\/strong>a) Physico-chemical properties of drug<br>b) Nature of the dosage form<br>c) Physiological factors<br>d) Pharmacogenetic factors<\/li>\n\n\n\n<li>e) Disease states.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>It is the rate and amount of drug that is absorbed from a given dosage form and reaches thesystemic circulation following non-vascular administration. When the drug is given IV, thebioavailability is 100%. It is important to know the manner in which a drug is absorbed. Theroute of administration largely determines the latent period between administration [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":6501,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[689],"tags":[],"class_list":["post-6532","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general-pharmacology"],"jetpack_featured_media_url":"https:\/\/workhouse.sweetdishy.com\/wp-content\/uploads\/2024\/11\/pharmacology-2.png","_links":{"self":[{"href":"https:\/\/workhouse.sweetdishy.com\/index.php\/wp-json\/wp\/v2\/posts\/6532","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/workhouse.sweetdishy.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/workhouse.sweetdishy.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/workhouse.sweetdishy.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/workhouse.sweetdishy.com\/index.php\/wp-json\/wp\/v2\/comments?post=6532"}],"version-history":[{"count":1,"href":"https:\/\/workhouse.sweetdishy.com\/index.php\/wp-json\/wp\/v2\/posts\/6532\/revisions"}],"predecessor-version":[{"id":6533,"href":"https:\/\/workhouse.sweetdishy.com\/index.php\/wp-json\/wp\/v2\/posts\/6532\/revisions\/6533"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/workhouse.sweetdishy.com\/index.php\/wp-json\/wp\/v2\/media\/6501"}],"wp:attachment":[{"href":"https:\/\/workhouse.sweetdishy.com\/index.php\/wp-json\/wp\/v2\/media?parent=6532"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/workhouse.sweetdishy.com\/index.php\/wp-json\/wp\/v2\/categories?post=6532"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/workhouse.sweetdishy.com\/index.php\/wp-json\/wp\/v2\/tags?post=6532"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}